noun / verb
anguish
ANG-gwish/ˈæŋɡwɪʃ/
Severe mental or physical suffering.
The man sits in anguish, clutching his head with both hands.

Etymology
Latin angustia described tightness or narrowness and, figuratively, distress. Anguish carries that image of painful constriction into severe bodily or mental suffering.
In context
she lost all desire for food and refused like others who were suffering great mental anguish