noun / verb
challenge
CHAL-inj/ˈtʃælɪndʒ/
A demand to prove one's ability or a claim's validity.
The steep climb presents a serious challenge to the exhausted hikers.
Etymology
From calumnia’s sense of malicious accusation, challenge developed meanings of objection and a call to fight. A difficult task similarly confronts someone with a test, without the earlier implication of wrongdoing.
In context
This is one main challenge for um for um pharmacology clinically. So, if you want to get drugs into the brain, it's often quite difficult to do.
More examples
- She challenges him to a rematch.
- The lawyer files a challenge to the ruling.
- The new role challenges her to learn unfamiliar skills.
Forms
challenge · challenges · challenged · challenging
challenging adjective — Demanding effort, skill, or determination.