noun
defect
DEE-fekt/ˈdiːfekt/
A flaw or imperfection.
A cracked tooth creates a defect in the metal gear.

Etymology
The 'away' and 'do, make' components formed a verb meaning 'fail.' Its noun named a lack, especially of something essential to completeness, leading to the sense of a flaw or imperfection.
In context
So, a septal defect could mean an opening and oxygen-rich blood could mix with oxygen-poor blood. Depending on the size, this can cause future problems such as an abnormal heartbeat