DictionarydespiteNot prevented by
preposition

despite

dih-SPYTE/dɪˈspaɪt/

Without being prevented by

The runner continues forward despite the driving rain and strong headwind.

Runner continues resolutely through slanting rain while headwind pushes jacket back, forward stride undeterred by bad weather.
Etymology

To “look down on” people is to treat them with contempt. The preposition comes from “in despite of,” meaning “in defiance or contempt of,” which developed into acting without being prevented by something.

In context

Frank Tufano8:47
One other thing vegans always like to dismiss is tool usage, despite blending all of their meals in a Vitamix, despite using a knife to cut open all of the fruits he's eating.
Raw Fruit Boy finds Bliss in Infertility

More examples

  • Despite several delays, the train arrives before noon.
  • He stays cheerful despite feeling tired.
  • The team loses despite its best efforts.

Similar words

notwithstanding
More formal; often appears in legal or official writing.
regardless
Used with “of” to emphasize that something makes no difference.