verb
impair
im-PAIR/ɪmˈper/
To weaken or damage something's quality or ability to function.
The broken strands impair the rope's ability to support the heavy bucket.

Etymology
Latin peiorare supplies the idea of making something worse. Impairing something lowers its condition or effectiveness, whether by weakening its function or damaging its quality.
In context
this response is disregulated which doesn't necessarily mean excessive but it is enough to impair normal functioning of the body we said that circulation is compromised in sepsis
More examples
- The injury impaired her hearing in one ear.
- Excess moisture can impair the sensor's performance.
- Smoke is impairing visibility along the highway.
Forms
impair · impairs · impaired · impairing
impairment noun — Damage that reduces normal function or ability.