noun
pestilence
PES-tih-luns/ˈpestɪləns/
A deadly infectious disease spreading through a population.
Pestilence spreads through the crowded city, claiming lives every day.

Etymology
Latin pestilentia could mean a plague or an unwholesome atmosphere. The selected English sense preserves the disease meaning: a fatal epidemic, rather than merely unhealthy conditions.
In context
shall not do much hurt but when the air of any one of our towns shall be so corrupted as to spread and maintain the pestilence in it
More examples
- The village loses half its population to pestilence.
- Doctors struggle to contain the pestilence before it reaches neighboring towns.
- Fear of pestilence keeps travelers away from the port.
Forms
pestilence · pestilences
pestilential adjective — Causing or spreading deadly infectious disease.