verb
preclude
prih-KLOOD/prɪˈkluːd/
To prevent something from happening or being possible.
The padlocked gate precludes passage through the entrance.

Etymology
“Before” and “shut” give the image of shutting something off in advance. Preclude applies that image to preventing an event or closing off a possibility.
In context
What sort of challenges, aches, pains, or unfulfilled dreams preclude us from experiencing joy?
More examples
- An earlier commitment precluded her attendance.
- The rule does not preclude further discussion.
- Lack of evidence precludes a firm conclusion.
Forms
preclude · precludes · precluded · precluding
preclusion noun — the prevention of a possibility