noun / adjective
problem
PRAH-blum/ˈprɑːbləm/
A matter that requires an answer or resolution.
The cyclist examines the broken chain to find the problem.

Etymology
The original image is something “thrown forward”: a question or task put before someone for consideration. From a question proposed for solution, the word broadened to a difficulty needing resolution.
In context
the problem of studying crystal structure in polymorphism experimentally is of course that it's very very difficult to know exactly what structure you're creating
More examples
- The last math problem requires two calculations.
- We solve the storage problem by adding shelves.
- The inspector checks each problem area for leaks.
Forms
problem · problems
problematic adjective — Causing difficulty or requiring careful resolution.
Similar words
- difficulty
- Emphasizes the trouble involved rather than the need for an answer.
- question
- Focuses on something to answer, not necessarily a troublesome situation.