DictionarysclerosisTissue hardening
noun

sclerosis

skluh-ROH-sis/skləˈrəʊsɪs/

Pathological hardening of living tissue.

The artery wall resists gentle pressure because sclerosis makes it rigid.

A close-up comparison of two arterial tissue specimens: a healthy, supple artery visibly yields under forceps, while a diseased artery with a thickened, calcified wall stays rigid under the same gentle compression.
Etymology

The pieces express a condition of hardness. In medical use, this means tissue becoming abnormally hard, rather than retaining its normal softness or flexibility.

In context

Neuroscientifically Challenged0:42
Multiple sclerosis is characterized by damage to the myelin sheaths surrounding the axons of neurons in the central nervous system.
2-Minute Neuroscience: Multiple Sclerosis

More examples

  • The biopsy reveals sclerosis in the damaged tissue.
  • Imaging shows sclerosis in the bone beneath the joint.
  • The report describes mild sclerosis of the aortic valve.

Forms

sclerosis · scleroses

sclerotic adjective — Affected by abnormal hardening of tissue.

Similar words

fibrosis
Specifically involves excess fibrous tissue, which can cause hardening.
calcification
Specifically involves calcium deposits, which can make tissue hard.