noun
catastrophe
kuh-TAS-truh-fee/kəˈtæstrəfi/
A disaster or failure causing great harm or loss.
The flood leaves a broken bridge and a scene of catastrophe.

Etymology
“Down” and “turning” combine in the image of an overturning. The word described a reversal or fatal turning point in a drama before its meaning broadened to a sudden disaster.
In context
Gaza is suffering a humanitarian catastrophe and the situation is getting even worse now we continue to share the goal of seeing Hamas defeated