adjective / noun
refractory
rih-FRAK-tuh-ree/rɪˈfræktəri/
Resistant to an influence intended to change it.
The refractory mule resists the handler's gentle lead toward the gate.

Etymology
'Back' and 'break' are said to suggest 'breaking back' attempts to enforce obedience. That proposed image connects stubbornness with the wider sense of resisting control or treatment.
In context
patients who have refractory uh or difficult to manage uh psychiatric problems
More examples
- Her seizures remain refractory to standard treatment.
- Refractory bricks protect the kiln walls from intense heat.
- The furnace lining contains refractories that withstand extremely high temperatures.
Forms
refractory · refractories
refractoriness noun — The quality of resisting control or change.